Claudio Soto

Prions

The New Biology of Proteins

• Broschiertes Buch

Produktbeschreibung

This volume offers a well-organized overview of prion-related diseases. It reviews the symptoms, epidemiology, and neuropathology of the disease, and focuses on the idea that TSEs result from a novel mechanism involving transmission by replication of the misfolding of a single protein. The author, a renowned innovator in the area of neurodegenerative diseases, examines the structure, conversion, and mechanism of prion propagation and details its cellular biology. He also looks at other diseases that display folding aberrations, considers how common such aberrations are, and speculates on the impact of prions on broader areas of biology, public health, and biotechnological strategies.

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Produktdetails

• Verlag: Taylor & Francis Ltd (Sales)
• Seitenzahl: 192
• Erscheinungstermin: 23. Oktober 2019
• Englisch
• Abmessung: 226mm x 150mm x 15mm
• Gewicht: 386g
• ISBN-13: 9780367391454
• ISBN-10: 0367391457
• Artikelnr.: 58054251

Autorenporträt

Soto, Claudio

Inhaltsangabe

Prologue. Prion Diseases: Clinical Symptoms, Epidemiology and
Neuropathology. The Infectious Agent and the Prion Hypothesis. The Prion
Protein: Cell Biology, Genetic and Putative Function. Prion Replication by
Transmission of Protein Conformation. Prion Strains and Multiple
Conformations of the Prion Protein. Prions: From the Mouth to the Brain.
Neurodegeneration in Prion Disease. The Diagnosis Problem and Current
Tests. Therapeutic Approaches. Cyclic Amplification of Prion Protein:
Rationale, Application and Perspectives. Other Diseases of Protein
Misfolding. Prions: A Common Phenomenon in Biology?