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This book serves as both an introduction and a practical guide on the synthesis and use of polyphosphazenes, a new and very versatile polymer family which has recently demonstrated bioactivity, biocompatibility, and biodegradability. These polymers find uses as potent vaccine adjuvants and microencapsulating agents; biodegradable materials and scaffolds for tissue engineering; biocompatible coatings and carriers for gene delivery, for example. A broad spectrum of application specialists working in chemistry, life scientists, and chemical engineering will appreciate this single source reference.…mehr
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This book serves as both an introduction and a practical guide on the synthesis and use of polyphosphazenes, a new and very versatile polymer family which has recently demonstrated bioactivity, biocompatibility, and biodegradability. These polymers find uses as potent vaccine adjuvants and microencapsulating agents; biodegradable materials and scaffolds for tissue engineering; biocompatible coatings and carriers for gene delivery, for example. A broad spectrum of application specialists working in chemistry, life scientists, and chemical engineering will appreciate this single source reference.
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Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Produktdetails
- Produktdetails
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 480
- Erscheinungstermin: 1. August 2009
- Englisch
- Abmessung: 236mm x 155mm x 25mm
- Gewicht: 762g
- ISBN-13: 9780470193433
- ISBN-10: 0470193433
- Artikelnr.: 26431639
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 480
- Erscheinungstermin: 1. August 2009
- Englisch
- Abmessung: 236mm x 155mm x 25mm
- Gewicht: 762g
- ISBN-13: 9780470193433
- ISBN-10: 0470193433
- Artikelnr.: 26431639
Alexander K. Andrianov, PhD, is a Vice President of Research and Development at Apogee Technology, Inc. Dr. Andrianov has more than 25 years of experience in the discovery and development of novel polymers for biological applications, including biodegradable materials, vaccine adjuvants, macromolecules for microencapsulation, controlled release formulations, and transdermal drug delivery systems. He is an author of over 60 research manuscripts, review articles, and book chapters and an inventor with 41 issued and pending patents. Dr. Andrianov has been involved in all aspects of technology development and commercialization.
CONTRIBUTORS. PREFACE. I INTRODUCTION. 1 Polymers for Biology and Medicine
- Current Status and Future Prospects (Alexander K. Andrianov and Robert
Langer). 2 Expanding Options in Polyphosphazene Biomedical Research (Harry
R. Allcock). II VACCINE DELIVERY AND IMMUNOMODULATION. 3 Polyphosphazenes
as Vaccine Delivery Systems (Alexander K. Andrianov). 4 The Potential of
Polyphosphazenes in Modulating Vaccine-Induced Immune Responses I:
Investigations In Mice (George Mutwiri, Ponn Benjamin, Alexander K.
Andrianov, and Lorne Babiuk). 5 The Potential of Polyphosphazenes in
Modulating Vaccine-Induced Immune Responses II: Investigations In Large
Animals (George Mutwiri and Lorne Babiuk). 6 Polyphosphazenes as Adjuvants
for Inactivated and Subunit Rotavirus Vaccines in Adult and Infant Mice
(Kari Johansen, Jorma Hinkula, Claudia Istrate, Elin Johansson, Didier
Poncet, and Lennart Svensson). 7 Polyphosphazene Immunoadjuvants for
Intradermal Vaccine Delivery (Alexander K. Andrianov, Daniel P. DeCollibus,
Helice A. Gillis, Henry H. Kha, Alexander Marin). III BIOMATERIALS. 8
Biodegradable Polyphosphazene Scaffolds for Tissue Engineering (Syam P.
Nukavarapu, Sangamesh G. Kumbar, Harry R. Allcock and Cato T. Laurencin). 9
Biodegradable Polyphosphazene Blends for Biomedical Applications (Meng
Deng, Lakshmi S. Nair, Nicholas R. Krogman, Harry R. Allcock, Cato T.
Laurencin). 10 Polyphosphazenes from Condensation Polymerization (Patty
Wisian-Neilson). 11 Electrospun Polyphosphazene Nanofibers For In Vitro
Osteoblast Culture (Maria Teresa Conconi, Paolo Carampin, Silvano Lora,
Claudio Grandi, Pier Paolo Parnigotto). 12 Phosphazenes and Surfaces (Mario
Gleria, Roberto Milani, Roberta Bertani, Angelo Boscolo Boscoletto, and
Roger De Jaeger). IV DRUG DELIVERY SYSTEMS. 13 Amphiphilic Ionizable
Polyphosphazenes for the Preparation of pH-Responsive Liposomes (David
Ghattas and Jean-Christophe Leroux). 14 Poly- and Cyclophosphazenes as Drug
Carriers for Anticancer Therapy (Youn Soo Sohn and Yong Joo Jun). 15
Amphiphilic Polyphosphazenes as Drug Carriers (Liyan Qiu and Cheng Zheng).
16 Synthesis and Characterization of Organometallic Derivatives of
Polyphosphazenes and their Applications in Nanoscience (Carlos Diaz and M.
L. Valenzuela). 17 Transport Properties of Polyphosphazenes (Joel R.
Fried). V BIODETECTION. 18 Potentiometric Monitoring Antibody-Antigen
Interactions by and Stabilization of Polyanilineand Electrodes with
p-Sulfonated Poly(bisphenoxyphosphazene) (Byeongyeol Kim, Alexander K.
Andrianov, Alok Prabhu, Vladimir Sergeyev, and Kalle Levon). VI
WELL-DEFINED POLYPHOSPHAZENES: SYNTHETIC ASPECTS AND NOVEL MOLECULAR
ARCHITECTURES. 19 Synthesis and chemical regularity in phosphazene
copolymers (Gabino A. Carriedo). 20 Supramolecular Structures of
Cyclophosphazenes(Alexander Steiner APPENDIX A. INDEX.
- Current Status and Future Prospects (Alexander K. Andrianov and Robert
Langer). 2 Expanding Options in Polyphosphazene Biomedical Research (Harry
R. Allcock). II VACCINE DELIVERY AND IMMUNOMODULATION. 3 Polyphosphazenes
as Vaccine Delivery Systems (Alexander K. Andrianov). 4 The Potential of
Polyphosphazenes in Modulating Vaccine-Induced Immune Responses I:
Investigations In Mice (George Mutwiri, Ponn Benjamin, Alexander K.
Andrianov, and Lorne Babiuk). 5 The Potential of Polyphosphazenes in
Modulating Vaccine-Induced Immune Responses II: Investigations In Large
Animals (George Mutwiri and Lorne Babiuk). 6 Polyphosphazenes as Adjuvants
for Inactivated and Subunit Rotavirus Vaccines in Adult and Infant Mice
(Kari Johansen, Jorma Hinkula, Claudia Istrate, Elin Johansson, Didier
Poncet, and Lennart Svensson). 7 Polyphosphazene Immunoadjuvants for
Intradermal Vaccine Delivery (Alexander K. Andrianov, Daniel P. DeCollibus,
Helice A. Gillis, Henry H. Kha, Alexander Marin). III BIOMATERIALS. 8
Biodegradable Polyphosphazene Scaffolds for Tissue Engineering (Syam P.
Nukavarapu, Sangamesh G. Kumbar, Harry R. Allcock and Cato T. Laurencin). 9
Biodegradable Polyphosphazene Blends for Biomedical Applications (Meng
Deng, Lakshmi S. Nair, Nicholas R. Krogman, Harry R. Allcock, Cato T.
Laurencin). 10 Polyphosphazenes from Condensation Polymerization (Patty
Wisian-Neilson). 11 Electrospun Polyphosphazene Nanofibers For In Vitro
Osteoblast Culture (Maria Teresa Conconi, Paolo Carampin, Silvano Lora,
Claudio Grandi, Pier Paolo Parnigotto). 12 Phosphazenes and Surfaces (Mario
Gleria, Roberto Milani, Roberta Bertani, Angelo Boscolo Boscoletto, and
Roger De Jaeger). IV DRUG DELIVERY SYSTEMS. 13 Amphiphilic Ionizable
Polyphosphazenes for the Preparation of pH-Responsive Liposomes (David
Ghattas and Jean-Christophe Leroux). 14 Poly- and Cyclophosphazenes as Drug
Carriers for Anticancer Therapy (Youn Soo Sohn and Yong Joo Jun). 15
Amphiphilic Polyphosphazenes as Drug Carriers (Liyan Qiu and Cheng Zheng).
16 Synthesis and Characterization of Organometallic Derivatives of
Polyphosphazenes and their Applications in Nanoscience (Carlos Diaz and M.
L. Valenzuela). 17 Transport Properties of Polyphosphazenes (Joel R.
Fried). V BIODETECTION. 18 Potentiometric Monitoring Antibody-Antigen
Interactions by and Stabilization of Polyanilineand Electrodes with
p-Sulfonated Poly(bisphenoxyphosphazene) (Byeongyeol Kim, Alexander K.
Andrianov, Alok Prabhu, Vladimir Sergeyev, and Kalle Levon). VI
WELL-DEFINED POLYPHOSPHAZENES: SYNTHETIC ASPECTS AND NOVEL MOLECULAR
ARCHITECTURES. 19 Synthesis and chemical regularity in phosphazene
copolymers (Gabino A. Carriedo). 20 Supramolecular Structures of
Cyclophosphazenes(Alexander Steiner APPENDIX A. INDEX.
CONTRIBUTORS. PREFACE. I INTRODUCTION. 1 Polymers for Biology and Medicine
- Current Status and Future Prospects (Alexander K. Andrianov and Robert
Langer). 2 Expanding Options in Polyphosphazene Biomedical Research (Harry
R. Allcock). II VACCINE DELIVERY AND IMMUNOMODULATION. 3 Polyphosphazenes
as Vaccine Delivery Systems (Alexander K. Andrianov). 4 The Potential of
Polyphosphazenes in Modulating Vaccine-Induced Immune Responses I:
Investigations In Mice (George Mutwiri, Ponn Benjamin, Alexander K.
Andrianov, and Lorne Babiuk). 5 The Potential of Polyphosphazenes in
Modulating Vaccine-Induced Immune Responses II: Investigations In Large
Animals (George Mutwiri and Lorne Babiuk). 6 Polyphosphazenes as Adjuvants
for Inactivated and Subunit Rotavirus Vaccines in Adult and Infant Mice
(Kari Johansen, Jorma Hinkula, Claudia Istrate, Elin Johansson, Didier
Poncet, and Lennart Svensson). 7 Polyphosphazene Immunoadjuvants for
Intradermal Vaccine Delivery (Alexander K. Andrianov, Daniel P. DeCollibus,
Helice A. Gillis, Henry H. Kha, Alexander Marin). III BIOMATERIALS. 8
Biodegradable Polyphosphazene Scaffolds for Tissue Engineering (Syam P.
Nukavarapu, Sangamesh G. Kumbar, Harry R. Allcock and Cato T. Laurencin). 9
Biodegradable Polyphosphazene Blends for Biomedical Applications (Meng
Deng, Lakshmi S. Nair, Nicholas R. Krogman, Harry R. Allcock, Cato T.
Laurencin). 10 Polyphosphazenes from Condensation Polymerization (Patty
Wisian-Neilson). 11 Electrospun Polyphosphazene Nanofibers For In Vitro
Osteoblast Culture (Maria Teresa Conconi, Paolo Carampin, Silvano Lora,
Claudio Grandi, Pier Paolo Parnigotto). 12 Phosphazenes and Surfaces (Mario
Gleria, Roberto Milani, Roberta Bertani, Angelo Boscolo Boscoletto, and
Roger De Jaeger). IV DRUG DELIVERY SYSTEMS. 13 Amphiphilic Ionizable
Polyphosphazenes for the Preparation of pH-Responsive Liposomes (David
Ghattas and Jean-Christophe Leroux). 14 Poly- and Cyclophosphazenes as Drug
Carriers for Anticancer Therapy (Youn Soo Sohn and Yong Joo Jun). 15
Amphiphilic Polyphosphazenes as Drug Carriers (Liyan Qiu and Cheng Zheng).
16 Synthesis and Characterization of Organometallic Derivatives of
Polyphosphazenes and their Applications in Nanoscience (Carlos Diaz and M.
L. Valenzuela). 17 Transport Properties of Polyphosphazenes (Joel R.
Fried). V BIODETECTION. 18 Potentiometric Monitoring Antibody-Antigen
Interactions by and Stabilization of Polyanilineand Electrodes with
p-Sulfonated Poly(bisphenoxyphosphazene) (Byeongyeol Kim, Alexander K.
Andrianov, Alok Prabhu, Vladimir Sergeyev, and Kalle Levon). VI
WELL-DEFINED POLYPHOSPHAZENES: SYNTHETIC ASPECTS AND NOVEL MOLECULAR
ARCHITECTURES. 19 Synthesis and chemical regularity in phosphazene
copolymers (Gabino A. Carriedo). 20 Supramolecular Structures of
Cyclophosphazenes(Alexander Steiner APPENDIX A. INDEX.
- Current Status and Future Prospects (Alexander K. Andrianov and Robert
Langer). 2 Expanding Options in Polyphosphazene Biomedical Research (Harry
R. Allcock). II VACCINE DELIVERY AND IMMUNOMODULATION. 3 Polyphosphazenes
as Vaccine Delivery Systems (Alexander K. Andrianov). 4 The Potential of
Polyphosphazenes in Modulating Vaccine-Induced Immune Responses I:
Investigations In Mice (George Mutwiri, Ponn Benjamin, Alexander K.
Andrianov, and Lorne Babiuk). 5 The Potential of Polyphosphazenes in
Modulating Vaccine-Induced Immune Responses II: Investigations In Large
Animals (George Mutwiri and Lorne Babiuk). 6 Polyphosphazenes as Adjuvants
for Inactivated and Subunit Rotavirus Vaccines in Adult and Infant Mice
(Kari Johansen, Jorma Hinkula, Claudia Istrate, Elin Johansson, Didier
Poncet, and Lennart Svensson). 7 Polyphosphazene Immunoadjuvants for
Intradermal Vaccine Delivery (Alexander K. Andrianov, Daniel P. DeCollibus,
Helice A. Gillis, Henry H. Kha, Alexander Marin). III BIOMATERIALS. 8
Biodegradable Polyphosphazene Scaffolds for Tissue Engineering (Syam P.
Nukavarapu, Sangamesh G. Kumbar, Harry R. Allcock and Cato T. Laurencin). 9
Biodegradable Polyphosphazene Blends for Biomedical Applications (Meng
Deng, Lakshmi S. Nair, Nicholas R. Krogman, Harry R. Allcock, Cato T.
Laurencin). 10 Polyphosphazenes from Condensation Polymerization (Patty
Wisian-Neilson). 11 Electrospun Polyphosphazene Nanofibers For In Vitro
Osteoblast Culture (Maria Teresa Conconi, Paolo Carampin, Silvano Lora,
Claudio Grandi, Pier Paolo Parnigotto). 12 Phosphazenes and Surfaces (Mario
Gleria, Roberto Milani, Roberta Bertani, Angelo Boscolo Boscoletto, and
Roger De Jaeger). IV DRUG DELIVERY SYSTEMS. 13 Amphiphilic Ionizable
Polyphosphazenes for the Preparation of pH-Responsive Liposomes (David
Ghattas and Jean-Christophe Leroux). 14 Poly- and Cyclophosphazenes as Drug
Carriers for Anticancer Therapy (Youn Soo Sohn and Yong Joo Jun). 15
Amphiphilic Polyphosphazenes as Drug Carriers (Liyan Qiu and Cheng Zheng).
16 Synthesis and Characterization of Organometallic Derivatives of
Polyphosphazenes and their Applications in Nanoscience (Carlos Diaz and M.
L. Valenzuela). 17 Transport Properties of Polyphosphazenes (Joel R.
Fried). V BIODETECTION. 18 Potentiometric Monitoring Antibody-Antigen
Interactions by and Stabilization of Polyanilineand Electrodes with
p-Sulfonated Poly(bisphenoxyphosphazene) (Byeongyeol Kim, Alexander K.
Andrianov, Alok Prabhu, Vladimir Sergeyev, and Kalle Levon). VI
WELL-DEFINED POLYPHOSPHAZENES: SYNTHETIC ASPECTS AND NOVEL MOLECULAR
ARCHITECTURES. 19 Synthesis and chemical regularity in phosphazene
copolymers (Gabino A. Carriedo). 20 Supramolecular Structures of
Cyclophosphazenes(Alexander Steiner APPENDIX A. INDEX.