1. Introduction: From Physiology to DNA and Back.- 2. RNA Chain Initiation and Promoter Escape by RNA Polymerase.- 3. Transcription Termination and Its Control.- 4. Codon Context, Translational Step-Times and Attenuation.- 5. Control by Antisense RNA.- 6. Translational Control of Gene Expression in E. Coli and Bacteriophage.- 7. Effects of DNA Supercoiling on Gene Expression.- 8. The HU and IHF Proteins: Accessory Factors for Complex Protein-DNA Assemblies.- 9. The lac and gal Operons Today.- 10. The Maltose System.- 11. The Phosphoenolpyruvate-Dependent Carbohydrate: Phosphotransferase System (PTS) and Control of Carbon Source Utilization.- 12. The Cap Modulon.- 13. Regulation of Nitrogen Assimilation.- 14. History of the Pho System.- 15. Are the Multiple Signal Transduction Pathways of the Pho Regulon Due to Cross Talk or Cross Regulation?.- 16. The FNR Modulon and FNR-Regulated Gene Expression.- 17. The NAR Modulon Systems: Nitrate and Nitrite Regulation of Anaerobic Gene Expression.- 18. Regulation of Aerobic and Anaerobic Metabolism by the Arc System.- 19. The Porin Regulon: A Paradigm for the Two-Component Regulatory Systems.- 20. The LeucineLrp Regulon.- 21. Adaptive responses to Oxidative Stress: The soxRS and oxyR Regulons.- 22. The SOS Regulatory System.- 23. Heat Shock Regulation.- 24. Roles for Energy-Dependent Proteases in Regulatory Cascades.- 25. Control of rRNA and Ribosome Synthesis.- 26. Cell Division.- 27. Regulation of Gene Expression in Stationary Phase.