Hepatitis C infection not only causes liver diseases but shows extrahepatic manifestations and immunological disorders. The aim of the present work is to study extrahepatic oral lesions that present with viral hepatitis C, as well as to detect HCV in the cells of these lesions and to find the role of this virus in their pathogenesis. This study was applied on twenty HCV +ve patients with different oral lesions. The present study revealed that HCV infection may play a role in the pathogenesis of some oral pathological