Immacolata Castellano, Antonello Merlino

Gamma-Glutamyl Transpeptidases

Structure and Function

• Broschiertes Buch

Produktbeschreibung

Gamma-Glutamyl Transpeptidases (Gamma-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the Gamma-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released Gamma-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). Gamma-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.Gamma-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson's disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of Gamma-GTs and gives information about applications of Gamma-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.

Produktdetails

• SpringerBriefs in Biochemistry and Molecular Biology
• Verlag: Springer / Springer Basel / Springer, Basel
• Artikelnr. des Verlages: 978-3-0348-0681-7
• 2013
• Seitenzahl: 68
• Erscheinungstermin: 25. Juli 2013
• Englisch
• Abmessung: 235mm x 155mm x 5mm
• Gewicht: 119g
• ISBN-13: 9783034806817
• ISBN-10: 3034806817
• Artikelnr.: 38106852

Inhaltsangabe

1 Introduction.- 2 Occurrence, genes and gene expression.- 3 Structure and function of Gamma-GTs.- 4 Autoprocessing and reaction mechanism of Gamma-GTs.- 5 Gamma-GT in bioclinical.- 6 Gamma-GTs: biotechnological and biomedical applications.- 7 Conclusions.- References.