Pramod Kumar Biswal, Manoj Kumar Mishra, Anupam Singh Bhaodouriya

Dual Drug Action of Drug Delivery System

• Broschiertes Buch

Produktbeschreibung

The purpose of the present research was to produce a quick/slow biphasic delivery system for Diclofenac Sodium. A dual component tablet made of a sustained release tableted core and an immediate release tableted coat was prepared by direct compression. Both the core and the coat contained a model drug (Diclofenac Sodium). The sustained release effect was achieved with a polymer (Microcrystalline cellulose) to modulate the release of the drug. The in vitro drug release profile from these tablets showed the desired biphasic release behavior: the Diclofenac Sodium contained in the fast releasing component was dissolved within 2 minutes, whereas the drug in the core tablet was released at different times (=16 or 924 hours), depending on the composition of the matrix tablet. Based on the release kinetic parameters calculated, it can be concluded that the Micro Crystalline core was suitable for providing a constant and controlled release (zero order) for a long period of time.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 80
• Erscheinungstermin: 29. September 2015
• Englisch
• Abmessung: 220mm x 150mm x 5mm
• Gewicht: 137g
• ISBN-13: 9783659787454
• ISBN-10: 3659787450
• Artikelnr.: 43965452

Autorenporträt

I am Pramod Kumar Biswal, currently working as Assistant Professor in Kunuwar Haribansh Singh college of Pharmacy, Jaunpur, U.P., India.