The Genetics of Coeliac Disease in Malta - Borg, Joseph;Xuereb Christopher Vidal, Angela A.;Scerri, Christian A.
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Two polymorphisms found within the CTLA4 gene were studied amongst a sample of coeliac patients and cord blood DNA samples that acted as the control group. Polymorphisms within the CTLA4 gene have been associated with other autoimmune conditions and the gene plays a very important role in immuno-regulatory function. The coeliac individuals and cord blood samples were genotyped for the -318 C/T and +49 A/G single nucleotide polymorphisms. No association of the single polymorphisms or the combined haplotypes with the coeliac condition was apparent amongst the coeliac patients under study. The…mehr

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Produktbeschreibung
Two polymorphisms found within the CTLA4 gene were studied amongst a sample of coeliac patients and cord blood DNA samples that acted as the control group. Polymorphisms within the CTLA4 gene have been associated with other autoimmune conditions and the gene plays a very important role in immuno-regulatory function. The coeliac individuals and cord blood samples were genotyped for the -318 C/T and +49 A/G single nucleotide polymorphisms. No association of the single polymorphisms or the combined haplotypes with the coeliac condition was apparent amongst the coeliac patients under study. The -318 C allele and the +49 A allele were in linkage disequilibrium amongst the cord blood samples.
Autorenporträt
El Dr. Joseph Borg B.Sc M.Sc PhD trabaja como científico investigador en el Laboratorio de Genética Molecular de la Universidad de Malta. El trabajo presentado aquí es el primer estudio sobre la genética de la enfermedad celíaca en Malta. También sentó las bases de una gran colección de pacientes familiares y parientes con la enfermedad celíaca.