Hanan Ahmed, Abdelfattah Badawi, Ahmed Fify

Applications of Novel Substituted Biphenyl-Sulfonamides

INTRODUCTION MATERIALS AND METHODS, EXPERIMENTAL PART, RESULTS AND DISCUSSION

• Broschiertes Buch

Produktbeschreibung

The objectives of this work is comparing three different kinds of sulfonamide compounds by evaluating structure modification through their examination towards more important properties such as: (a) Surface properties of the synthesized sulfonamide compounds were studied through surface parameters cmc,(cmc), A(min) and (max). Most of these tested compounds have remarkable surface activity. (b) The target compounds were tested to determine structure-biological activity relationship against different types of pathogenic bacterial species. The amine acid salts of bis (2-aminophenyl) biphenyl-4,4'-disulfonamide (Series B) were the powerfully effective series. Only carboxylic acid salts of bis (2-aminophenyl)biphenyl-4,4'- disulfonamide (Series B) were powerfully effective series against selected pathogenic fungal species. (c) Selected compounds were screened for cytotoxicity against selected human tumor cell lines MCF7, HEPG2, and HCT116. Most of tested compounds have potent cytotoxicactivity against liver carcinoma and colon carcinoma, meanwhile, exhibit moderate activity against breast carcinoma.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 100
• Erscheinungstermin: 12. August 2010
• Englisch
• Abmessung: 220mm x 150mm x 6mm
• Gewicht: 167g
• ISBN-13: 9783838387390
• ISBN-10: 3838387392
• Artikelnr.: 31208682

Autorenporträt

Hanan El-Sharkawy Ali Ahmed is an associate professor in the Surfactant Laboratory, Petrochemicals Department, Egyptian Petroleum Research Institute (EPRI). She earned her Ph.D. in Organic Chemistry in 2003, and her M.Sc. in Organic Chemistry in 1999, both from the College of Women, Ain Shams University, Cairo, Egypt.