The work has been carried out at Bhopal Memorial Hospital and Research Center, Bhopal, MP, India,with the objective to analyze the immunotoxic and genotoxic effects of Methyl Isocyanate on human lymphocytes. The work has mainly emphasized on the ill-effects, victims of Bhopal Gas Tragedy suffered from, then in 1984.One of the effects, Oxidative stress, has been determined by different techniques to design better approaches in future for risk management.