Helminths infection of animals causes significant loss in live stock production and productivity. Chemical and non chemical methods are commonly used to control helminths of which chemotherapy by anthelmintics is the most widely used. How ever anthelmintic use is constrained by wide spread development of anthelmintic resistance. In this paper attempts were made to indicate control methods of helminths, mechanism of resistance, risk factors, and techniques of detecting anthelmintic resistance. The status and control of anthelmintic resistance in small ruminants in Ethiopia and some common helminthes found in Ethiopia also reviewed briefly.