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Indian Medicinal Plants are potential source as therapeutic agents, in present book attempts were made to search for novel leads from certain Indian Medicinal Plants. Plants are chemical factories. These are reservior of Natural Products and isolation of pure bioactive from plants and their use as Antimicrobial and Antioxidant Agents was current target. The objective of the present investigation was to analyze antimicrobial and antioxidant potential of Ayurvedic drugs (Gorakhmundi, Palaspapda, Lodar, Lasora, Mulethi, Dhaniya, Ajwain, Medalakri, Samudraphal and Morandi). These results will also be supported with phytochemical screening to justify the presence of various secondary metabolites as a therapeutic agents for future use as drug for mankind.Authors are thankful to our Directors (Shri Amit Agarwal and Arpit Agarwal, Mahatma Gandhi Institute of Applied Sciences, JECRC Foundation, Jaipur, India) for their everlasting support. Prof. C. K. Ojha Sir, for kind guidance. Department of Science and Technology, Jaipur for their support.