Comparative Analysis of Contacts Between Crystal Lattice & Oligo Interface - Jaiswal, Ashish Kumar
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G proteins are molecular amplifiers. GTPases are a large family of enzymes that can bind and hydrolyze GTP. The GTP binding and hydrolysis takes place in the highly conserved G domain common to all GTPases. Protein crystal contacts are weak and generally form only under conditions designed to limit protein solubility and maximize protein-2 interactions. However, they do form with a kind of specificity, at least in the sense that only certain contacts are repeated within each unit cell of any particular crystal packing arrangement. For oligomeric proteins, amino acids at the subunit interfaces…mehr

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Produktbeschreibung
G proteins are molecular amplifiers. GTPases are a large family of enzymes that can bind and hydrolyze GTP. The GTP binding and hydrolysis takes place in the highly conserved G domain common to all GTPases. Protein crystal contacts are weak and generally form only under conditions designed to limit protein solubility and maximize protein-2 interactions. However, they do form with a kind of specificity, at least in the sense that only certain contacts are repeated within each unit cell of any particular crystal packing arrangement. For oligomeric proteins, amino acids at the subunit interfaces have been selected in order to maintain affinity and specificity properties. Many proteins contain highly flexible or even completely unfolded fragments that dramatically interfere with crystallization conditions. These conditions are the crystal lattice and Oligomeric interface or proteins that allow the residues to bind in such a specific way by which the crystallization of GTPase is fast.This book therefore, should be helpful for better understanding the crystallograpgy of proteins for biologists etc.
Autorenporträt
Mr. Jaiswal earned his MS in Bioinformatics from CCS University India 2005. He has many publications during his 13 years of research experience at various institutes (ICAR, ICMR, NYUAD). He published a course book on Cell Biology at PTU India. Currently, he is working as Research Associate & Bioinformatician at NYU Abu Dhabi since 2012.