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The aims of this monograph were to investigate the genetic polymorphisms of tumor necrosis factor alpha and transforming growth factor-beta 1 in different disorders. We focused on such gastrointestinal, autoimmune, hematological diseases, where the overproduction of these cytokines might be a predominant factor in the pathomechamisms, or where anti-TNF therapy has been introduced. In a close connection the single nucleotid polymorphisms of CD14 and heat shock protein 70-2 genes were also analyzed. The present study was designed to determine the correlation of TNF-alpha, HSP70-2, and CD14 gene…mehr

Produktbeschreibung
The aims of this monograph were to investigate the genetic polymorphisms of tumor necrosis factor alpha and transforming growth factor-beta 1 in different disorders. We focused on such gastrointestinal, autoimmune, hematological diseases, where the overproduction of these cytokines might be a predominant factor in the pathomechamisms, or where anti-TNF therapy has been introduced. In a close connection the single nucleotid polymorphisms of CD14 and heat shock protein 70-2 genes were also analyzed. The present study was designed to determine the correlation of TNF-alpha, HSP70-2, and CD14 gene polymorphisms and the severity of acute pancreatitis. The prevalence of TNF-alpha and HSP70-2 gene polymorphisms in a family with rheumatoid arthritis was also investigated. The prognostic value of TNF-alpha gene polymorphism among patients treated with anti-TNF-alpha therapy, and the effect of anti-TNF-alpha therapy on TNF-alpha production and apoptosis was also determined. Finally, the association between TNF-alpha and TGF-ß1 gene polymorphism and the susceptibility to myelodysplastic syndrome was investigated.
Autorenporträt
Attila Balog graduated with an M.D. from Univ.of Szeged, Hungary (2001). He holds his Ph.D. also there (2005). He was an national expert (2005-2006) of JRC-IRMM, Belgium. He is assisstant professor (level 1) of Dept. of Rheumatology. He is interested in pathomechanism of rheumatoid arthritis and spondylitis ankylopoetica. He published 16 papers.