A prospective cross sectional study was carried out on women who attended the family planning and gynaecologic unit of the Dschang District Hospital and other healthcare centres. This study determined the types, risk factors, pathogens of sexually transmitted diseases and other genital infections; and the in vitro susceptibility profile of the most commonly isolated bacterial pathogen to ten antibiotics by a disc diffusion method on Mueller Hinton agar. Out of the 1820 women encountered in this study, 1024 ( 56.3%)women were presenting symptoms of sexually transmitted diseases and other genital infections while 796 (43,7%) were asymptomatic for these infections. Major determinants of genital infections were unprotected sexual intercourse, promiscuity, extra marital sexual practices, multiple sexuality, poverty, poor personal and environmental hygiene, frequent wearing of tight fitting clothes and synthetic underwear, the use of medicated soaps to clean the genitalia, and immunosuppression ( pregnancy and AIDS). Vancomycin (100%), gentamycin (91.7%), augmentin (87.7%), ciprofloxacin (81.3%), and streptomycin (81.0%) had high in-vitro efficacy against S. aureus strains.