The regeneration of the periodontal tissues is dependent on four basic components: appropriate signals, cells, blood supply and scaffold need to target the tissue defect. Each of these elements play a fundamental role on the healing process and is interconnected into the generation of new tissues. Growth factors modulate the cellular activity and provide stimuli to cells to differentiate and produce matrix toward the developing tissue. Here an attempt is made to gather the available data on various growth factors and their role in periodontology.