Various statistical and mathematical tools have been used in the research to study and analyze the factors affecting human health, including the environment, as a result of application of which human health status, risk of loss of life in different age and gender groups of population of the Republic of Armenia (RA) and size of its economic damage have been estimated. Based on the aforementioned, a system-oriented analysis has been conducted in the paper, the objective of which is the substantiation of environmental factors affecting human health. Based on the urgency of solution of the issues presented, a very insightful and professional analysis has been conducted wherein the relevance of the topic lays.