Nagapattinam coast remained highly vulnerable to the vagaries of natural disasters for a long time. Keeping in view the demands of the society, this research work has been undertaken to assess the vulnerability of the Nagapattinam coastline, which extends from Porto Novo in the north to Adhiramapattinam in the south. CVI was computed and a comparison was made between classical and sigmoidal CVI. Static inundation analysis was done for the sea level rises by 1m, 2m, 3m, 4m and 5m, and the towns and villages expected to be severely affected were mapped. Aquifer Vulnerability Index was calculated using GALDIT model to study the vulnerability of Nagapattinam coastal aquifers to saline water intrusion. Finally, a multi-hazard zonation map was prepared to demarcate areas that are affected by all the identified hazards. Suitable management strategies are proposed to mitigate the risks.