Shemsia Mohamed Hudie, Ghirma Moges

Determination of the Antiretroviral Drug Lamivudine

by Potentiometric Titration using All Solid State Graphite Based Iodide Selective Electrode

• Broschiertes Buch

Produktbeschreibung

A solid-state iodide selective electrode with Ag2S-AgI adsorbed on graphite rod, recovered from a dry cell, was prepared and validated for its typical response characteristics with an objective to develop a potentiometric titration system for rapid measurements of Lamuvidine (LMV) in tablets used as an antiretroviral drug for Hepatis B and HIV patients. The partial validationexhibited typical response values of linear range of 10-6 to 10-1 M iodide and a slope 57.57 mV/decade which reasonably agreed with early data from our Laboratory.The basis of LMV determination is its oxidation by excess bromine generated from bromate-bromide mixture. The unreacted bromine oxidized the added excess iodide to iodine. The amount of bromine consumed by LMV, the basis of its determination, was determined by subtracting the back-titrated iodine with thiosulphate whose end-point was located potentiometrically with the solid state iodide selective electrode against a reference electrode. The iodometric back titration provided for the indirect determination of 1-30 mg LMV in turbid tablet test solutions.

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Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Aufl.
• Seitenzahl: 60
• Erscheinungstermin: 24. Oktober 2011
• Englisch
• Abmessung: 220mm x 150mm x 4mm
• Gewicht: 107g
• ISBN-13: 9783846528778
• ISBN-10: 3846528773
• Artikelnr.: 34430262

Autorenporträt

I am a highly enthusiastic professional always trying hard to fulfill my goals to grow professionally and spritually which is indispensable for the well being of human kind. born and grown up in a beautiful town Bahirdar, Ethiopia. Currently i am a lecturer in analytical chemistry,at one of the oldest universities in Ethiopia, Haremaya university.