Diabetes Mellitus is a chronic disease that leads to long-term damage and dysfunction of various organs, such as the eyes, kidneys, nerves, heart, and blood vessels. Diabetic keratopathy is a significant ocular complication of diabetes that leads to persistent corneal epithelial defects and is a major cause of blindness due to its deviation from the normal wound healing process. Despite its significance, the pathogenic mechanism of diabetic keratopathy remains elusive and has received less attention compared to other diabetic complications due to its latent and chronic nature.