What every neuroscientist should know about the mathematical modeling of excitable cells, presented at an introductory level.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Greg Conradi Smith is a Professor in the Department of Applied Science and Neuroscience Program Faculty Affiliate at the College of William and Mary, Virginia. He was organizer of the Cold Spring Harbor Laboratory Summer School on Computational Cell Biology (2008-14). His research focuses on mathematical aspects of cell physiology and neuroscience.
Inhaltsangabe
1. Introduction Part I. Models and Odes: 2. Compartmental modeling 3. Phase diagrams 4. Ligands, receptors and rate laws 5. Function families and characteristic times 6. Bifurcation diagrams of scalar ODEs Part II. Passive Membranes: 7. The Nernst equilibrium potential 8. The current balance equation 9. GHK theory of membrane permeation Part III. Voltage-Gated Currents: 10. Voltage-gated ionic currents 11. Regenerative ionic currents and bistability 12. Voltage-clamp recording 13. Hodgkin-Huxley model of the action potential Part IV. Excitability and Phase Planes: 14. The Morris-Lecar model 15. Phase plane analysis 16. Linear stability analysis Part V. Oscillations and Bursting: 17. Type II excitability and oscillations 18. Type I excitability and oscillations 19. The low-threshold calcium spike 20. Synaptic currents.
1. Introduction Part I. Models and Odes: 2. Compartmental modeling 3. Phase diagrams 4. Ligands, receptors and rate laws 5. Function families and characteristic times 6. Bifurcation diagrams of scalar ODEs Part II. Passive Membranes: 7. The Nernst equilibrium potential 8. The current balance equation 9. GHK theory of membrane permeation Part III. Voltage-Gated Currents: 10. Voltage-gated ionic currents 11. Regenerative ionic currents and bistability 12. Voltage-clamp recording 13. Hodgkin-Huxley model of the action potential Part IV. Excitability and Phase Planes: 14. The Morris-Lecar model 15. Phase plane analysis 16. Linear stability analysis Part V. Oscillations and Bursting: 17. Type II excitability and oscillations 18. Type I excitability and oscillations 19. The low-threshold calcium spike 20. Synaptic currents.
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