Developmental toxicity in lead exposed rats:Reversal effect of calcium - Rajarami Reddy, Gottipolu; Chand Basha, Davuljigari
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Early life exposure to Pb altered the cholinergic, aminergic and antoxidant systems, associated with motor functions of developing and young rats. These impairments in motor functions and neurochemical parameters (cholinergic, aminergic and mitochondrial antioxidant enzymes) remain for long after Pb exposure has stopped. Supplementation with calcium reversed the Pb induced neurotoxicity by modifying the motor functions and restoring the specific enzyme activities and neurotransmitters. Adequate calcium intake will be beneficial to reduce Pb induced neurotoxicity during development of rat brain.…mehr

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Produktbeschreibung
Early life exposure to Pb altered the cholinergic, aminergic and antoxidant systems, associated with motor functions of developing and young rats. These impairments in motor functions and neurochemical parameters (cholinergic, aminergic and mitochondrial antioxidant enzymes) remain for long after Pb exposure has stopped. Supplementation with calcium reversed the Pb induced neurotoxicity by modifying the motor functions and restoring the specific enzyme activities and neurotransmitters. Adequate calcium intake will be beneficial to reduce Pb induced neurotoxicity during development of rat brain.
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Autorenporträt
Dr Gottipolu R. Reddy, Ph.D., is a Vice- Chancellor and Professor of Zoology at Vikrama Simhapuri University,Nellore, India. Prof. Reddy has been working on heavy metal neurotoxicology with special attention on lead (Pb) and has established the therapeutic potential of essential metal supplements to reverse heavy metal toxicity.