Isolation of Cobra Venom Cytotoxin FVIb - Gaber, Dalia Ali;El-Asmer, Mohamed Farid;Zaki, Kamelia Ahmed
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The search for cancer cure from natural products have been practiced for over a century. For the last 25 years, El-Asmer and co-workers were pursuing the search for potential therapeutic agent or new drug models from snake venoms. This work was presented for partial fulfillment of M.D. in Biochemistry. A cytolytic, non-antigenic, 8 kDa, glycoprotein (Fraction VIb) was isolated from crude Naja nigricollis nigricollis spitting cobra venom. This protein is stable at different pH values and different temperatures up to 100ºC, lethal to mice, with LD50 1.83 mg/kg. Small doses induced cytolytic…mehr

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Produktbeschreibung
The search for cancer cure from natural products have been practiced for over a century. For the last 25 years, El-Asmer and co-workers were pursuing the search for potential therapeutic agent or new drug models from snake venoms. This work was presented for partial fulfillment of M.D. in Biochemistry. A cytolytic, non-antigenic, 8 kDa, glycoprotein (Fraction VIb) was isolated from crude Naja nigricollis nigricollis spitting cobra venom. This protein is stable at different pH values and different temperatures up to 100ºC, lethal to mice, with LD50 1.83 mg/kg. Small doses induced cytolytic effect on hepatocellular carcinoma, colon cancer and breast cancer cells while larger doses caused hemolysis of red blood cells. Thus, this protein can be considered a target compound for further researches as it can be a potential bio-therapeutic agent for cancer treatment, or a model for new drug design.
Autorenporträt
Dr. Dalia Ali Gaber studied medicine at Ain Shams University, Cairo, Egypt. She obtained her MD degree from Ain Shams faculty of medicine, 2011. She works as Lecturer of Biochemistry at Misr University for Science & Technology,Giza, Egypt .