Damian Maseda Caballero

Non-canonical pre-TCR signaling during T cell development

• Broschiertes Buch

Produktbeschreibung

T cells undergoing maturation in the thymus need to receive a pre-TCR-delivered signal to undergo ¿-selection and develop further properly. The pre-TCR is composed of a constitutively expressed pre-T¿ (pT¿) chain and a de novo expressed TCR¿ chain. A productive recombination of the TCR¿ chain is mandatory to overcome the first checkpoint that controls T cells survival. However, in a very low but consistent extent, thymocytes lacking a canonical pre-TCR can differentiate further. We show that thymocytes lacking a classical pre-TCR can survive and differentiate to later developmental stages. Besides, signaling through a pT¿-less TCR is enough to achieve Ca2+ influx and NF-¿B activation. In addition, we demonstrate that the mechanisms underlying cell death of thymocytes in conditions of proteasome inhibition are in great extent independent of NF-¿B activation and pre-TCR or TCR signaling, and are rather dependent on triggering the pro-apoptotic terminal UPR.

Produktdetails

• Verlag: LAP LAMBERT Academic Publishing
• Seitenzahl: 104
• Erscheinungstermin: 23. März 2016
• Englisch
• Abmessung: 220mm x 150mm x 7mm
• Gewicht: 173g
• ISBN-13: 9783659857614
• ISBN-10: 3659857610
• Artikelnr.: 62632610

Autorenporträt

As a broadly-trained immunologist and biologist I am focused on immune regulation and acquired immune responses. I study the integration of autoimmunity and inflammatory events in diseases like colitis (IBD), Rheumatoid Arthritis, Lupus and Type-1 Diabetes.