Currently, pure titanium and titanium alloys are considered a great choice in producing various medical devices such as implants or prostheses compared with other metals. Their specific properties, such as good biocompatibility, lower toxicity grade and excellent corrosion resistance are making them the most promising metals used in the biomedical field. The family of titanium (Ti) biomaterials presents a low or no reaction with surrounding tissues. However, many surface treatments are needed in order to fulfill all the requirements for an adequate host response. Numerous research have been made to discover the real potential of this metal and its alloys and various techniques were recently developed to treat the metal surface with biologically active coatings, so as to obtain a rapid osseointegration, a minimum risk of infection after surgery and to prevent the microbial attachment and biofilm development starting with the first stages.