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Laktobacilly - wazhnyj komponent estestwennoj mikroflory cheloweka i zhiwotnyh. Oni intensiwno ispol'zuütsq w proizwodstwe probioticheskih preparatow i produktow funkcional'no pitaniq. U bakterij Lactobacillus plantarum wperwye obnaruzhen i oharakterizowan specifichnyj NO-sintaznyj put' obrazowaniq oxida azota. Namecheny podhody k ocenke fiziologicheskogo smysla biosinteza NO kletkami laktobacill. Uchastie mikrobnogo oxida azota w stress-reakciqh bakterij pozwolqet rassmatriwat' NO kak uniwersal'nyj faktor stressornogo i adaptiwnogo otwetow kletok razlichnogo urownq organizacii.Lactobacilli are an important component of human and animal microflora. They are widely used in production of probiotics and functional food. Using EPR and NO-specific fluorescent probes we for the first time showed and characterized specific NO-synthase-derived way of NO production in Lactobacillus plantarum.Physiological functions of NO production in lactobacilli were outlined. Out data indicate involvement of microbial NO in bacterial stress response, thus allowing us to consider NO as the universal stress limiting and adaptation factor in organisms differing in the level of organization.