Earl Prohofsky

Statistical Mechanics and Stability of Macromolecules

Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA

• Broschiertes Buch

Produktbeschreibung

This book develops a statistical mechanical analysis of the stability of biological macromolecules. The author's approach is valid both for the long time-scale needed for DNA bond disruption, and also for highly cooperative transitions needed to explain helix melting. Prohofsky develops a new theoretical approach for executing macromolecule calculations. In particular the author devises a method for describing chemical bond disruption in these large systems, which is then used to determine when the helix melts and how drugs can dissociate from the helix. The author finds melting temperatures to be in excellent agreement with experimental observations.

Produktdetails

• Verlag: Cambridge University Press
• Seitenzahl: 240
• Erscheinungstermin: 13. Mai 2005
• Englisch
• Abmessung: 234mm x 156mm x 13mm
• Gewicht: 371g
• ISBN-13: 9780521675574
• ISBN-10: 052167557X
• Artikelnr.: 21320245

Inhaltsangabe

Preface
1. Introduction
2. Macromolecular stability
3. Lattice dynamics
4. Effective phonon theory
5. Premelting disrupted chemical bonds
6. Co-operative melting
7. Strained chemical bonds: salt and pressure effects
8. Bond disruption and conformation change: B to Z confirmation change in DNA
9. Hydration effects: structural water
10. Helix with daunomycin intercalated: increased helix stability and daunomycin-DNA bonding constant
11. Non repeating DNA
12. Cutting and splicing: junctions, inserts and the replicating fork
13. Interaction between a helix and a single attached molecule
14. Energy considerations in bond opening
Appendix 1
Appendix 2
Appendix 3. Index