This study explores the effects of culture on management, specifically the middle level and low-level managers at the University of Nairobi. Some factors were singled out in order to understand their impact on management. The study further made use of previous research findings which provided a basis for carrying out the research. The key instruments used in the field to collect data were questionnaires and interviews. The data collected was analysed using Statistical Package for Social Sciences (SPSS). This study came up with various findings. First it discovered that bureaucracy involved in procurement and unequal treatments of all managers at the university were the leading aspects that affect managers in their day to day duties. Second, the chain of command from top level to bottom in the hierarchy is long and sometimes makes it difficult for low level managers to express their views to their top managers. Finally, it was found out that government policy has not contributed to improvement of organizational culture in the organization under study. Finally it made several recommendations on organizational culture.