The most up-to-date summary of current statistical research in personalized medicine, ideal for a broad audience of medical researchers.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Michael R. Kosorok is W. R. Kenan, Jr Distinguished Professor and Chair of Biostatistics and Professor of Statistics and Operations Research at the University of North Carolina, Chapel Hill. He is an honorary fellow of both the American Statistical Association and the Institute of Mathematical Statistics and an Associate Editor of The Annals of Statistics, the Journal of the American Statistical Association, and the Journal of the Royal Statistical Society, Series B. He is the contact principal investigator for a program project (P01) from the US National Cancer Institute, entitled 'Statistical Methods for Cancer Clinical Trials'. His main research interests are in precision medicine, clinical trials, machine learning, and related areas.
Inhaltsangabe
List of contributors; List of figures; Preface; 1. Introduction M. R. Kosorok and E. E. M. Moodie; Part I. Design of Trials for Estimating Dynamic Treatment Regimes: 2. DTRs and SMARTs: definitions, designs, and applications K. M. Kidwell; 3. Efficient design for clinically relevant intent-to-treat comparisons R. Dawson and P. W. Lavori; 4. SMART design, conduct, and analysis in oncology P. F. Thall; 5. Sample size calculations for clustered SMART designs P. Ghosh, Y. K. Cheung and B. Chakraborty; Part II. Practical Challenges in Dynamic Treatment Regime Analyses: 6. Analysis in the single-stage setting: an overview of estimation approaches for dynamic treatment regimes M. P. Wallace and E. E. M. Moodie; 7. G-estimation for dynamic treatment regimes in the longitudinal setting D. A. Stephens; 8. Outcome weighted learning methods for optimal dynamic treatment regimes Y. Q. Zhao; 9. Value search estimators for optimal dynamic treatment regimes M. Davidian, A. A. Tsiatis and E. B. Laber; 10. Evaluation of longitudinal dynamics with and without marginal structural working models M. Petersen, J. Schwab, E. Geng and M. J. van der Laan; 11. Imputation strategy for SMARTs S. M. Shortreed, E. B. Laber, J. Pineau and S. A. Murphy; 12. Clinical trials for personalized dose finding G. Chen and D. Zeng; 13. Methods for analyzing DTRs with censored survival data G. S. Johnson, A. Topp and A. S. Wahed; 14. Outcome weighted learning with a reject option M. Yuan; 15. Estimation of dynamic treatment regimes for complex outcomes: balancing benefits and risks K. A. Linn, E. B. Laber and L. A. Stefanski; 16. Practical reinforcement learning in dynamic treatment regimes R. D. Vincent, J. Pineau, N. Ybarra and I. El Naqa; 17. Reinforcement learning applications in clinical trials Y. F. Zhao; Bibliography; Index.
List of contributors; List of figures; Preface; 1. Introduction M. R. Kosorok and E. E. M. Moodie; Part I. Design of Trials for Estimating Dynamic Treatment Regimes: 2. DTRs and SMARTs: definitions, designs, and applications K. M. Kidwell; 3. Efficient design for clinically relevant intent-to-treat comparisons R. Dawson and P. W. Lavori; 4. SMART design, conduct, and analysis in oncology P. F. Thall; 5. Sample size calculations for clustered SMART designs P. Ghosh, Y. K. Cheung and B. Chakraborty; Part II. Practical Challenges in Dynamic Treatment Regime Analyses: 6. Analysis in the single-stage setting: an overview of estimation approaches for dynamic treatment regimes M. P. Wallace and E. E. M. Moodie; 7. G-estimation for dynamic treatment regimes in the longitudinal setting D. A. Stephens; 8. Outcome weighted learning methods for optimal dynamic treatment regimes Y. Q. Zhao; 9. Value search estimators for optimal dynamic treatment regimes M. Davidian, A. A. Tsiatis and E. B. Laber; 10. Evaluation of longitudinal dynamics with and without marginal structural working models M. Petersen, J. Schwab, E. Geng and M. J. van der Laan; 11. Imputation strategy for SMARTs S. M. Shortreed, E. B. Laber, J. Pineau and S. A. Murphy; 12. Clinical trials for personalized dose finding G. Chen and D. Zeng; 13. Methods for analyzing DTRs with censored survival data G. S. Johnson, A. Topp and A. S. Wahed; 14. Outcome weighted learning with a reject option M. Yuan; 15. Estimation of dynamic treatment regimes for complex outcomes: balancing benefits and risks K. A. Linn, E. B. Laber and L. A. Stefanski; 16. Practical reinforcement learning in dynamic treatment regimes R. D. Vincent, J. Pineau, N. Ybarra and I. El Naqa; 17. Reinforcement learning applications in clinical trials Y. F. Zhao; Bibliography; Index.
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