Chondrogenesis Of Co-Cultured Human Adipose-Derived Stem Cells - Choy Yee Wa, Ewa
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Articular cartilage is known to have a deficient capability for tissue regeneration due to lack of vasculature. Cartilage regeneration remains challenging despite the extensive research for the past decade. Cell-based therapies are the most promising approach among all cartilaginous treatment for clinical application. However, cell sourcing, culture-expansion, and chondrogenic differentiation remains a challenge in cell-based tissue engineering. Previous studies have shown co-cultured in alginate constructs play a pivotal role in cell cross-talk for successful cartilaginous regeneration. Given…mehr

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Produktbeschreibung
Articular cartilage is known to have a deficient capability for tissue regeneration due to lack of vasculature. Cartilage regeneration remains challenging despite the extensive research for the past decade. Cell-based therapies are the most promising approach among all cartilaginous treatment for clinical application. However, cell sourcing, culture-expansion, and chondrogenic differentiation remains a challenge in cell-based tissue engineering. Previous studies have shown co-cultured in alginate constructs play a pivotal role in cell cross-talk for successful cartilaginous regeneration. Given that multipotent human adipose-derived stem cells (ADSCs) have therapeutic potential for cartilage defect; the cell-cell interactions between ADSCs and human nasal chondroctyes (NCs) for promoting chondrogenesis in a three dimensional culture environment of alginate hydrogel was investigated.
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Autorenporträt
Ewa holds a Bachelor of Engineering in Biomedical and a Master of Medical Science in Physiology. She has been actively involved in research for the past 5 years. Her research interest is on genetic engineering and regeneration of cartilage using adult stem cells. She has authored few publications in scientific journals.