Fabien Pinaud

Peptide-coated Quantum Dots

Applications to Biological Imaging of Single Molecules in Live Cells and Organisms

• Broschiertes Buch

Produktbeschreibung

There is little doubt that recent advances in
material sciences and nanotechnology will contribute
to the development of new therapeutics and permit
new discoveries in medical and biological sciences.
Already, nanomaterials such as semiconductor
nanocrystals, also known as quantum dots, have
revolutionized cell and animal imaging techniques.
The stringent conditions imposed by complex
biological milieus demand that these nanomaterials
be stable and biocompatible. Toward this aim, this
thesis introduces an original surface chemistry that
employs custom-designed peptides as an
organic/inorganic interface on the surface of
quantum dots. This peptide coating strategy was
successfully tested on quantum dots emitting from
the visible to the near-infrared spectrum range.
Using the versatile physico-chemical properties of
peptides, a toolkit was developed to functionalize
quantum dots and control their biochemical activity
at the nanometer scale. Peptide-coated quantum dots
were engineered for in vivo animal imaging and
employed to study the diffusion and the
compartmentalization of lipid raft-associated
membrane proteins, one at a time, in live cells.

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 172
• Englisch
• Gewicht: 242g
• ISBN-13: 9783639085327
• ISBN-10: 3639085329
• Artikelnr.: 25951171

Autorenporträt

Fabien Pinaud received his PhD in Biochemistry and Molecular
Biology from the University of California in Los Angeles in
2007. He is a Marie-Curie and an EMBO Fellow currently
conducting research on quantum dots and single molecule cellular
imaging at the Ecole Normale Supérieure in Paris.