Polymorphism of Adiponectin and TCF7L2 Genes in Iraqi T2DM - Kaftan, Ahmed;Hassoon, Farah;Kadhum, Majid
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Type 2 diabetes mellitus (T2DM) is one of the major medical issues of the twenty one century, and till now there is no definite and exact cause of this disease, so many genetic studies was done on this field. some of these studies have shown that polymorphisms on chromosome ten and three within the adiponectin gene rs266729 and transcription factor 7-like 2 (TCF7L2) gene rs7903146 respectively are associated with type 2 diabetes (T2DM).from these polymorphisms is SNP rs266729 in adiponectin gene, and SNP rs7903146 in TCF7l2 gene.and these polymorphisms can cause variations in BMI , lipid…mehr

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Produktbeschreibung
Type 2 diabetes mellitus (T2DM) is one of the major medical issues of the twenty one century, and till now there is no definite and exact cause of this disease, so many genetic studies was done on this field. some of these studies have shown that polymorphisms on chromosome ten and three within the adiponectin gene rs266729 and transcription factor 7-like 2 (TCF7L2) gene rs7903146 respectively are associated with type 2 diabetes (T2DM).from these polymorphisms is SNP rs266729 in adiponectin gene, and SNP rs7903146 in TCF7l2 gene.and these polymorphisms can cause variations in BMI , lipid profile and insulin sensitivity. This study has confirmed that rs266729 of adiponectin gene significantly increase the risk of T2DM although its not for rs7903146 of TCF7l2 gene and this possibly due to genetic variations between populations.
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Autorenporträt
Dr.Ahmed Kaftan has obtained M.B.Ch.B from Kufa university in 2009 , and MSc Degree in clinical biochemistry from Kufa university also in 2014.He is a member of teaching staff in Kufa college of medicine.He worked on biochemical and genetic associations of T2DM in Iraqi population.He planned for future work on genetic expression of T2DM.