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In many countries of the world, among chronic inflammatory diseases of the joints, morbidity and disability rates due to reactive arthritis are increasing. In the research of a number of scientists, a doubling of the incidence of reactive arthritis has been observed over the last thirty years, and the incidence rate among the population of different countries is 0.2%-0.68%. In developed countries, the average age of reactive arthritis patients is 35 years, and the percentage of women among patients has increased by 30%. According to the opinions formed in recent years, the pathogenesis of reactive arthritis is based on immunological disturbances, and in 88-96% of cases, an inadequate cytostatic immunological response to the HLA-B27-antigen. Although ideas about its etiopathogenetic mechanisms have been created, the different nature of the joint syndrome causes scientists to form different, sometimes contradictory opinions. The main goal of such therapy is to reduce the main symptoms of the joint syndrome, while protecting against damage expected in the structure of the ankle tissue during the progression of arthrosis.