Fred F.H. Menko

Genetics of Colorectal Cancer for Clinical Practice

• Gebundenes Buch

Produktbeschreibung

Colorectal cancer is a collective term for a heterogeneous group of diseases. In a large proportion of cases, the condition is attributable to genetic predisposition. Those directly involved in the treatment of patients with cancer of the large bowel are confronted to an increasing degree with the genetic aspects of the disease. In familial and hereditary forms of the disorder periodic screening of the close relatives of the patients can in principle prevent disease and death from colorectal cancer. Presymptomatic diagnosis by means of DNA technology is now possible in many cases of familial adenomatous polyposis. Genetic diagnosis will be increasingly important for the identification of high-risk groups.
This book summarizes those aspects of the genetics of colorectal cancer that are important for clinical pracice. It has been stated that clinicians can contribute to the goal of reducing mortality from cancer by asking each patient about his or her family history of cancer. The aim of this book is to provide a guideline for the management of those situations in which the family history of colorectal cancer is found to be positive.

Produktdetails

• Developments in Oncology 72
• Verlag: Springer / Springer Netherlands
• Artikelnr. des Verlages: 978-0-7923-2100-2
• 1993.
• Seitenzahl: 204
• Erscheinungstermin: 31. Juli 1993
• Englisch
• Abmessung: 241mm x 160mm x 16mm
• Gewicht: 467g
• ISBN-13: 9780792321002
• ISBN-10: 0792321006
• Artikelnr.: 21659235

Inhaltsangabe

Preface. Introduction. 1: Genetic Predisposition and Illness:
Introduction. 1.1. Genes and Environment. 1.2. Modes of Inheritance. 1.3.
Autosomal Dominant Inheritance. 1.4. Studies at the DNA Level. 2: General
Aspects of Colorectal Cancer: Introduction. 2.1. Incidence and Mortality.
2.2. The Role of Diet. 2.3. Tumour Localisation and Histological Types.
2.4. The Adenoma--Carcinoma Sequence. 2.5. Estimation of Risk for
Colorectal Cancer. 2.6. Population Screening. 2.7. Groups at Increased Risk
for Colorectal Cancer. 2.8. Intervention Studies. 3: Familial and
Hereditary Colorectal Cancer: Introduction. 3.1. Family Studies of Patients
with Colorectal Cancer. 3.2. Classification: Polyposis and Nonpolyposis
Forms. 3.3. Hereditary Colorectal Cancer without Polyposis. 3.4.
Hereditary Colorectal Cancer with Polyposis. 3.5. Intermediate and
Miscellaneous Forms. 3.6. Risk Estimation for Family Members. 3.7.
Screening of High-Risk Family Members. 3.8. Psychosocial Aspects of
Familial Cancer. 4: Mechanisms of Colorectal Carcinogenesis: Introduction.
4.1. Chromosomal Abnormalities. 4.2. Oncogenes and Tumour Suppressor Genes.
4.3. DNA Repair and Immunological Mechanisms. 4.4. Proliferation
Biomarkers. 4.5. Tumour Biomarkers. 5: Clinical Examples. 6: Guidelines for
Clinical Practice. Bibliography. Index.

Rezensionen

'This book is well written and provides an excellent overview of hereditary colorectal cancer for all clinicians confronted with patients with colorectal cancer. It is hoped that this book will find broad clinical acceptance.' -- ECC Newsletter, 3:2

'It is presented in an attractive format and is highly recommended.' -- Cancer Forum, 18:3

`This book is well written and provides an excellent overview of hereditary colorectal cancer for all clinicians confronted with patients with colorectal cancer. It is hoped that this book will find broad clinical acceptance.'
ECC Newsletter, 3:2

`It is presented in an attractive format and is highly recommended.'
Cancer Forum, 18:3

`This book is well written and provides an excellent overview of hereditary colorectal cancer for all clinicians confronted with patients with colorectal cancer. It is hoped that this book will find broad clinical acceptance.'
ECC Newsletter, 3:2

`It is presented in an attractive format and is highly recommended.'
Cancer Forum, 18:3