Psychosocial problem and Quality of life is an important aspect of human life and this domain is especially concern of study for those people who are diagnosed as orthopedic handicapped. This research has carried out in various rehabilitation centers at Hyderabad named Sweekaar Rehabilitation Institute for Handicapped and National Institute for Mentally Handicapped, during the period of 2010 - 2011.The book Psychosocial problems and Quality of life in persons with Orthopedic Handicapped help to maintain and to keep stability in quality of life those who diagnosed.Book includes five chapters with references; it explains various psycho-social problems and quality of life of persons with orthopedic in detail.It was comparative experimental design with congenital and acquired group. The congenital group have poorer quality of life especially on two domains namely social relationship and environment except these domains and both groups are having same kind of psychosocial problems. Author also worked as a Rehabilitation Psychologist at Srujan Psychotherapy and Counselling Center, Maharashtra.