"A trade book on Alzheimer's disease--its human face, some insights into its biology, the discoveries that seemed a path to prevention if not cure, 25 years without progress, and a new path forward"--
"A trade book on Alzheimer's disease--its human face, some insights into its biology, the discoveries that seemed a path to prevention if not cure, 25 years without progress, and a new path forward"--
Karl Herrup is Professor of Neurobiology and an Investigator in the Alzheimer's Disease Research Center at the University of Pittsburgh School of Medicine. He is also Adjunct Professor of Life Science at the Hong Kong University of Science and Technology, where he was formerly Head of Life Sciences.
Inhaltsangabe
Prologue ix I In the Beginning 1 1 A Layperson's History of Alzheimer's Disease 3 2 A Physician's History of Alzheimer's Disease 23 3 A Scientist's History of Alzheimer's Disease 33 4 Mystery Solved! How Four Discoveries Transformed an Entire Field 53 II What Happened to our Cure? 71 5 Building a Model of Alzheimer's Disease 73 III Double-Edged Swords 97 6 Federal Support of Basic Biomedical Research 99 7 The Pharmaceutical and Biotech Industry 115 8 Testing Our Models: Breaking Bad 131 9 What is Alzheimer's Disease? 149 IV Where Shall We Go From Here? 169 10 A Layperson's Guide to the Biology of Aging 171 11 Building a New Model of Alzheimer's Disease 187 12 Rebalancing our Research Portfolio 207 13 Rebalancing our Institutions 227 14 Final Thoughts 243 Acknowledgments 247 Notes 249 Index 255
Prologue ix I In the Beginning 1 1 A Layperson's History of Alzheimer's Disease 3 2 A Physician's History of Alzheimer's Disease 23 3 A Scientist's History of Alzheimer's Disease 33 4 Mystery Solved! How Four Discoveries Transformed an Entire Field 53 II What Happened to our Cure? 71 5 Building a Model of Alzheimer's Disease 73 III Double-Edged Swords 97 6 Federal Support of Basic Biomedical Research 99 7 The Pharmaceutical and Biotech Industry 115 8 Testing Our Models: Breaking Bad 131 9 What is Alzheimer's Disease? 149 IV Where Shall We Go From Here? 169 10 A Layperson's Guide to the Biology of Aging 171 11 Building a New Model of Alzheimer's Disease 187 12 Rebalancing our Research Portfolio 207 13 Rebalancing our Institutions 227 14 Final Thoughts 243 Acknowledgments 247 Notes 249 Index 255
Prologue ix I In the Beginning 1 1 A Layperson's History of Alzheimer's Disease 3 2 A Physician's History of Alzheimer's Disease 23 3 A Scientist's History of Alzheimer's Disease 33 4 Mystery Solved! How Four Discoveries Transformed an Entire Field 53 II What Happened to our Cure? 71 5 Building a Model of Alzheimer's Disease 73 III Double-Edged Swords 97 6 Federal Support of Basic Biomedical Research 99 7 The Pharmaceutical and Biotech Industry 115 8 Testing Our Models: Breaking Bad 131 9 What is Alzheimer's Disease? 149 IV Where Shall We Go From Here? 169 10 A Layperson's Guide to the Biology of Aging 171 11 Building a New Model of Alzheimer's Disease 187 12 Rebalancing our Research Portfolio 207 13 Rebalancing our Institutions 227 14 Final Thoughts 243 Acknowledgments 247 Notes 249 Index 255
Prologue ix I In the Beginning 1 1 A Layperson's History of Alzheimer's Disease 3 2 A Physician's History of Alzheimer's Disease 23 3 A Scientist's History of Alzheimer's Disease 33 4 Mystery Solved! How Four Discoveries Transformed an Entire Field 53 II What Happened to our Cure? 71 5 Building a Model of Alzheimer's Disease 73 III Double-Edged Swords 97 6 Federal Support of Basic Biomedical Research 99 7 The Pharmaceutical and Biotech Industry 115 8 Testing Our Models: Breaking Bad 131 9 What is Alzheimer's Disease? 149 IV Where Shall We Go From Here? 169 10 A Layperson's Guide to the Biology of Aging 171 11 Building a New Model of Alzheimer's Disease 187 12 Rebalancing our Research Portfolio 207 13 Rebalancing our Institutions 227 14 Final Thoughts 243 Acknowledgments 247 Notes 249 Index 255
Rezensionen
In How Not to Study a Disease, a lucid, knowledgeable, but not entirely objective critique of the field of Alzheimer s research, Karl Herrup, a professor of neurobiology at the University of Pittsburgh School of Medicine, analyzes this challenge. He describes the complexity of even defining the disease; tells of the excitement of Alzheimer s research in the 1990s, when its cause was thought to be understood and treatments seemed imminent; and charts the long and expensive trickle of disappointment in the decades since, as it has become clear that the disease is much more complicated than was initially thought. As his title signals, Herrup criticizes the field for its adherence to a causal theory of Alzheimer s that he argues does not hold up. New York Review of Books
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