This richly illustrated Festschrift chronicles the company's development and contributions in the service of medicine and science since 1890, when the young bookseller Samuel Karger went into the medical publishing business in Berlin. His first book was a compact manual in obstetrics entitled 'Geburtshülfliches Vademecum'. Over the years, the company developed into an internationally active, now Swiss-based company which employs 250 people worldwide. The highly specialized Karger publishing program currently encompasses 100 journals and 50 new books per year across all biomedical disciplines.