Apoptosis related proteins p53 and Bcl-2 in hepatocellular carcinoma - Saad, Entsar;Toson, El-Shahat;El-Emshaty, Hoda
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Hepatitis B virus and hepatitis C virus may be involved in hepatocarcinogenesis in patients with HCC. These viral infections may be responsible, at least in a part, for the mutational change in the p53 gene and may affect the expression of the Bcl-2 protein in HCC patients. p53 and Bcl-2 proteins overexpression was detected in serum and tissues in HCC patients positive for hepatitis B or C or both and this overexpression was more frequently associated with HBV infection than HCV infection.

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Produktbeschreibung
Hepatitis B virus and hepatitis C virus may be involved in hepatocarcinogenesis in patients with HCC. These viral infections may be responsible, at least in a part, for the mutational change in the p53 gene and may affect the expression of the Bcl-2 protein in HCC patients. p53 and Bcl-2 proteins overexpression was detected in serum and tissues in HCC patients positive for hepatitis B or C or both and this overexpression was more frequently associated with HBV infection than HCV infection.
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Autorenporträt
Dr. Entsar A. Saad is Associate Professor of Biochemistry at Damietta University (Egypt). She completed her under and graduate studies with a Ph.D. from Mansoura University (Egypt). She is a member of the Egyptian Society of Biochemistry and Molecular Biology.