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Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) is still a challenging issue for the medical fraternity. There have been continuous efforts among the fraternity to take control of or to cure the disease,but yet to be completely successful. Further, HIV positive individuals also face a variety of challenges regarding health, quality of life and cognitive functioning to be on par with the mainstream. The current approaches towards addressing the issues are largely at physiological levels. While there are some attempts towards a wholesome approach for addressing the issues, there is a need to explore more options from an integrated approach, especially from an integrated yogic perspective.