Henry C. Lim

Fed-Batch Cultures (eBook, PDF)

Principles and Applications of Semi-Batch Bioreactors

• Format: PDF

Produktbeschreibung

Many, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background material regarding the 'what, why and how' of optimal and sub-optimal fed-batch operations. Numerous examples are provided to illustrate the application of optimal fed-batch cultures. This unique book, by world experts with decades of research and industrial experience, is a must for researchers and industrial practitioners of fed-batch processes (modeling, control and optimization) in biotechnology, fermentation, food, pharmaceuticals and waste treatment industries.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: Cambridge University Press
• Erscheinungstermin: 22. April 2013
• Englisch
• ISBN-13: 9781107330610
• Artikelnr.: 53188840

Autorenporträt

Dr Lim gained industrial experience by working for Pfizer for five years in areas of reaction engineering and separation and purification. He taught for twenty-one years at Purdue University and initiated biochemical engineering research in 1970. He was recruited to the University of California, Irvine, where he was founding chair of biochemical engineering and chemical engineering for ten years and taught for twenty-two years. He has extensive consulting experiences with Leeds and Northrup, Novo Enzyme Corporation, Pharmacontrol Inc., Eli Lilly, Merck, Monsanto, LG Biotech Inc., CJ Biotechnology and Zander Renewable Resources. He studied bioreactions and bioreactor engineering, modeling, optimization and control of bioreactors, cellular regulation, recombinant DNA technology and bioremediation. Dr Lim has supervised more than 50 PhD theses and published more than 160 journal articles and 2 books. He received the Food, Pharmaceutical and Bioengineering Division Award of the AIChE for his work on bioreactor and enzyme engineering.

Inhaltsangabe

1. Introduction to fed-batch bioreactors
2. Idealised reactors and fed-batch reactors
3. Maximisation of reaction rates and fed-batch operation
4. Phenomena that favour fed-batch operations
5. Classification and characteristics of fed-batch cultures
6. Models based on mass balance equations
7. Non-equation-based models
8. Experimental determination of specific rates
9. Optimization via Pontryagin's maximum principle
10. Computational techniques
11. Optimization of single and multiple isothermal reactions
12. Optimization of fed-batch cultures for cell mass production
13. Optimization of fed-batch cultures for metabolites
14. Simple, intuitive adaptive optimization
15. Measurements, estimation and control
16. Feasibility assessment and implementable feed rates.