L-Selectin P213S Polymorphism and Macrophage Profiles in Endometriosis - Siregar, Henry Salim
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Endometriosis is known as extra uterine presence of endometrial glands and stromas, and is associated with pelvic pain and infertility. It causes serious physical, mental, and social implications and is also an economic burden to the society. However, the pathogenesis is not fully understood. Several theories have been proposed to explain the histogenesis of endometriosis, including implantation, inflammmation, or genetic factors. Recently, the role of L-selectin in leukocyte extravasation and the role of macrophages in endometriosis have been extensively studied. Although yielding promising…mehr

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Produktbeschreibung
Endometriosis is known as extra uterine presence of endometrial glands and stromas, and is associated with pelvic pain and infertility. It causes serious physical, mental, and social implications and is also an economic burden to the society. However, the pathogenesis is not fully understood. Several theories have been proposed to explain the histogenesis of endometriosis, including implantation, inflammmation, or genetic factors. Recently, the role of L-selectin in leukocyte extravasation and the role of macrophages in endometriosis have been extensively studied. Although yielding promising results, previous studies have yet to determine the association between L-selectin and macrophages in human endometriosis. This monograph reports a breakthrough study that concluded L-selectin gene P213S polymorphism is associated with endometriosis and that M2 Macrophage has a significant role in developing endometriosis. On confirming the role it has on the events of endometriosis, togetherwith additional studies, L-selectin gene is expected to be a marker in diagnosing this disease.
Autorenporträt
Dr. Henry Salim Siregar completed his OB & GYN residency in 2000 at the University of Sumatra Utara and qualified as a consultant in Reprodctive Endocrinology and Fertility Medicine in 2010. He completed his doctoral program in 2014. He is now active as a lecturer, Head of the OB & GYN study program and an acknowledged gynecological endoscopist.