Renal transplantation is the treatment of choice of end stage renal disease. With the improvements in short and long term graft and patient survival after renal transplantation health related quality of life is becoming an important additional outcome parameter. Objective: to estimate the level of quality of life after renal transplantation and determine factors affecting quality of life. Method: the study was descriptive cross sectional using structured data collection form conducted on 298 participants in three hospitals in Khartoum state, SPSS and Excel were used for data analysis. Result: the study included 298 participants 70.1% male and 29.9% female, the mean of quality of life was found to be (73.9±15.9), physical functioning as the least score and emotional limitation as the highest score. 16 variables were found to affect the quality of life in Sudanese renal transplant recipients. Conclusion: the study showed that the mean of the total score of the health related quality of life was 73.9±15.9. The factors which significantly affect quality of life were most socio-demographic characteristic, difficulties regarding medications and and complications after transplantation.