This first book dealing exclusively with every aspect of fed-batch operations, used in most industrially important fermentation and bioreactor operations.
This first book dealing exclusively with every aspect of fed-batch operations, used in most industrially important fermentation and bioreactor operations.
Dr Lim gained industrial experience by working for Pfizer for five years in areas of reaction engineering and separation and purification. He taught for twenty-one years at Purdue University and initiated biochemical engineering research in 1970. He was recruited to the University of California, Irvine, where he was founding chair of biochemical engineering and chemical engineering for ten years and taught for twenty-two years. He has extensive consulting experiences with Leeds and Northrup, Novo Enzyme Corporation, Pharmacontrol Inc., Eli Lilly, Merck, Monsanto, LG Biotech Inc., CJ Biotechnology and Zander Renewable Resources. He studied bioreactions and bioreactor engineering, modeling, optimization and control of bioreactors, cellular regulation, recombinant DNA technology and bioremediation. Dr Lim has supervised more than 50 PhD theses and published more than 160 journal articles and 2 books. He received the Food, Pharmaceutical and Bioengineering Division Award of the AIChE for his work on bioreactor and enzyme engineering.
Inhaltsangabe
1. Introduction to fed-batch bioreactors 2. Idealised reactors and fed-batch reactors 3. Maximisation of reaction rates and fed-batch operation 4. Phenomena that favour fed-batch operations 5. Classification and characteristics of fed-batch cultures 6. Models based on mass balance equations 7. Non-equation-based models 8. Experimental determination of specific rates 9. Optimization via Pontryagin's maximum principle 10. Computational techniques 11. Optimization of single and multiple isothermal reactions 12. Optimization of fed-batch cultures for cell mass production 13. Optimization of fed-batch cultures for metabolites 14. Simple, intuitive adaptive optimization 15. Measurements, estimation and control 16. Feasibility assessment and implementable feed rates.
1. Introduction to fed-batch bioreactors 2. Idealised reactors and fed-batch reactors 3. Maximisation of reaction rates and fed-batch operation 4. Phenomena that favour fed-batch operations 5. Classification and characteristics of fed-batch cultures 6. Models based on mass balance equations 7. Non-equation-based models 8. Experimental determination of specific rates 9. Optimization via Pontryagin's maximum principle 10. Computational techniques 11. Optimization of single and multiple isothermal reactions 12. Optimization of fed-batch cultures for cell mass production 13. Optimization of fed-batch cultures for metabolites 14. Simple, intuitive adaptive optimization 15. Measurements, estimation and control 16. Feasibility assessment and implementable feed rates.
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