J. Donald Chapman, Alan E. Nahum

Radiotherapy Treatment Planning (eBook, ePUB)

Linear-Quadratic Radiobiology

• Format: ePub

Produktbeschreibung

This volume describes tumor cell inactivation from a radiation physics perspective and offers appropriate linear-quadratic parameters for modeling tumor and normal tissue responses. It describes cell killing by radiation from two independent mechanisms: alpha and beta. The authors emphasize the biophysical factors associated with radiation cell killing and provide numbers that can be input into TCP and NTCP models. They also explain how the physical factors of fraction size, dose rate, and radiation quality are used in radiotherapy.

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Produktdetails

• Verlag: Taylor & Francis
• Erscheinungstermin: 21. April 2016
• Englisch
• ISBN-13: 9781040219669
• Artikelnr.: 72524365

Autorenporträt

J. Donald Chapman provides consulting services to various radiation medicine commercial and academic organizations. His research has contributed to the fields of hypoxic radiosensitizing drugs, nuclear medicine markers of viable hypoxic cells, mechanisms of photodynamic therapy, and the killing of tumor cells by ionizing radiations. He has authored and co-authored over 200 articles in scientific journals and conference proceedings, served on the editorial boards of numerous radiation research journals, and received several international research awards. He earned a PhD in biophysics from the Pennsylvania State University.

Alan E. Nahum is head of physics research at Clatterbridge Cancer Centre and a visiting professor in the Department of Physics at Liverpool University. His current research focuses on radiobiologically guided treatment optimization through the individualization of tumor prescription and fractionation. He has edited and co-edited three books, including Handbook of Radiotherapy Physics: Theory and Practice, and authored and co-authored approximately 170 peer-reviewed papers, book chapters, and conference proceedings. He earned a PhD in theoretical radiation dosimetry from the University of Edinburgh.

Inhaltsangabe

Introduction. The Generation of Quantitative Radiobiology Data. Intrinsic
Radiosensitivity of Proliferating and Quiescent Cells. Effects of
Ionization Density and Volume. Impact of Fraction Size, Dose-Rate,
Temperature and Overall Treatment Time on Tumor Cell Response. Ionizing
Events, Molecular Targets and Lethal Lesions. The Radiosensitivity of Tumor
Cells In Vitro versus In Vivo. Modern Radiobiology and the LQ Equation.
Normal Tissues Radiobiology. Radiobiology Applied to Tumor Response
Modeling. Epilogue. References. Index.