The Multiple Myeloma SET Domain (MMSET) Protein - Marango, Jotin
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The t(4;14) translocation, present in ca. 20% of cases of Multiple Myeloma, results in the dysregulation of two potential oncogenes, MMSET and FGFR3, via juxtaposition to regulatory elements of the IgH locus. The presence of t(4;14) and overexpression of transcripts from the MMSET locus are adverse prognostic factors in Multiple Myeloma irrespective of FGFR3 expression, implicating MMSET in disease pathogenesis. MMSET is a biologically active transcriptional effector that could mediate a series of repressive changes by acting as a methyltransferase enzyme in chromatin remodeling and as a complex adaptor in the recruitment of repressor species.…mehr

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Produktbeschreibung
The t(4;14) translocation, present in ca. 20% of
cases of Multiple
Myeloma, results in the dysregulation of two
potential oncogenes,
MMSET and FGFR3, via juxtaposition to regulatory
elements of the IgH
locus. The presence of t(4;14) and overexpression of
transcripts from
the MMSET locus are adverse prognostic factors in
Multiple Myeloma
irrespective of FGFR3 expression, implicating MMSET
in disease
pathogenesis. MMSET is a biologically active
transcriptional effector
that could mediate a series of repressive changes by
acting as a
methyltransferase enzyme in chromatin remodeling and
as a complex
adaptor in the recruitment of repressor species.
Autorenporträt
Jotin Marango holds a BA with honors in Chemistry from Harvard
University, and a PhD
in Molecular Biology as well as an MD from the Mount Sinai School
of Medicine of New
York University. This book is based on his graduate doctoral
dissertation.