The purpose of the study was to explore the different factors that contribute to motivation among nurses working at Butare University Teaching Hospital in Rwanda. A quantitative, exploratory and descriptive research methodology was used to explore these factors, and non-probability convenience sampling was used to include the most readily available persons as participants. A convenient sample size of 106 nurses, positively selected using the Raosoft sample size calculator, was chosen. The criteria for inclusion in the sample were that participants should all be nurses (enrolled and registered) who had been working at the hospital for at least six months; who had completed their initial nurse training; who were present during the period of the study; and who consented to participate in the study. The data was collected using a structured questionnaire, which had closed- and open-ended questions. Data was analysed using SSPS 15.0 for Windows. The findings of the present study showed that the nurses at this hospital had a moderate level of motivation..