John P. Devlin

High Throughput Screening

The Discovery of Bioactive Substances

• Gebundenes Buch

Produktbeschreibung

Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high throughput screening (HTS) systems and provides a solid foundation for the implementation and development of HTS in bio-based industries and associated academic environments.

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Produktdetails

• Verlag: CRC Press
• Seitenzahl: 700
• Erscheinungstermin: 6. Mai 1997
• Englisch
• Abmessung: 260mm x 183mm x 42mm
• Gewicht: 1489g
• ISBN-13: 9780824700676
• ISBN-10: 0824700678
• Artikelnr.: 21083993

Autorenporträt

John P. Devlin

Inhaltsangabe

Natural Products as a Discovery Resource
edited by John P. Devlin Chemical Diversity and Genetic Equity: Synthetic and Naturally Derived Compounds
John P. Devlin Microcollection of Plants for Biochemical Profiling
John P. Devlin Enzymes and Microbes as a Source of Chemical Diversity
Saul L. Neidleman The Marine Environment as a Discovery Resource
Gregg R. Dietzman Compound Sourcing: Chemically Generated Screening Libraries
edited by Michael R. Pavia Introduction
Michael R. Pavia Rapidly Expanding Molecular Diversity: Libraries from Libraries
John S. Kiely
Barbara Dörner
John M. Ostresh
Colette Dooley
and Richard A. Houghten Synthesis of Encoded Small Molecule Combinatorial Libraries via ECLiPS
Jack J. Baldwin and Ian Henderson Parallel Organic Synthesis Using Parke-Davis' Diversomer® Method
Sheila Hobbs DeWitt and Anthony W. Czarnik Rapid Discovery and Optimization of Biologically Active Small Molecules Using Automated Synthesis Methods
Adnan M. M. Mjalli and Barry E. Toyonaga CMT: A Solution Phase Combinatorial Chemistry Approach: Synthesis and Yield Prediction Phenazines
Ferenc Darvas and László Kovács Design of a Diverse Screening Library
David E. Patterson
Allan M. Ferguson
Richard D. Cramer
Cheryl D. Garr
Ted L. Underiner
and John R. Peterson Automating Combinatorial Chemistry: Challenges and Pitfalls
Jill H. Hardin and Frank R. Smietana Combi-chem High Throughput Screening for Leads Optimization
Richard M. Kris
Patti Willson
Serene Josiah
Marianne Wildgoose
Helen Yeoman
Viktor Krchnak
Stephen Baum
and Stephen Felder Assay Technologies and Detection Methods
edited by Alfred J. Kolb Introduction
Alfred J. Koin Bioassay Design and Implementation
Robert W. Wallace and Mark E. Goldman Scintillation Proximity Assays
Martino Picardo and Kelvin T. Hughes FlashPlate(TM) Technology
Beverly A. Brown
Margaret Cain
Jeff Broadbent
Sharon Tompkins
Georgette Henrich
Rich Joseph
Sally Casto
Harry Harney
Rick Greene
Ron Delmondo
and Simon Ng Assays for Small Molecule Agonists and Antagonists of the Neurotrophin Receptors
Maureen H. Beresini
Michael D. Sadick
Amy L. Galloway
Randy Yen
Sherry H. Yeh
Andy C. Chang
David L. Shelton
and Wai Lee T. Wong A Homogeneous
Time-Resolved Fluorescence Method for Drug Discovery
Alfred J. Kolb
Jocelyn W. Burke
and Gerard Mathis Time-Resolved Fluorometry: Advantages and Potentials
Ilkka Hemmilä Adaptation of Time-Resolved Fluorescence to Homogeneous Screening Formats
Janet M. Kolb
Greg Yamanaka
and Susan P. Manly Fluorescence Polarization
J. Richard Sportsman
Sandra K. Lee
Hara Dilley
and Robert Bukar Reporter Gene Assay Applications
Winfried Scheirer Development of a Gene Expression-Based Screen Using Quantitative Polymerase Chain Reaction
D. K. H. Lee
E. T. Wilkinson
S. Cheifetz
and S. A. De Grandis High-Performance Microphysiometry in Drug Discovery
M. Liisa Alajoki
Gregory T. Baxter
William R. Bemiss
David Blau
Luc J. Bousse
Samuel D. H. Chan
Timothy D. Dawes
Karen M. Hahnenberger
James M. Hamilton
Philip Lam
Richard J. McReynolds
Douglas N. Modlin
John C. Owicki
J. Wallace Parce
Dana Redington
Knute Stevenson
H. Garrett Wada
and Jana Williams Bioanalytical Applications of BIAcore
an Optical Biosensor
Francois Legay
Patrick Albientz
and Rüdiger Ridder Automation and Robotics
edited by Alfred J. Kolb Introduction
Alfred J. Kolb Management and Service Issues of a Centralized Robotic HTS Core
John Babiak Flexible Use of People and Machines
Mark Beggs and John S. Major Bar-Code Technology and a Centralized Database: Key Components in a Radioligand Binding Program
Elizabeth A. Kunysz
Melissa Lukes
and Douglas W. Bonhaus Factors for the Successful Integration of Assays
Equipment
Robotics
and Software
Dejan Bojanic
Wilma W. Keighley
Mike J. Russell
and Terry P. Wood Accelerating the Discovery Process with Automation and Robotics: A Sure Bet or a Risky Venture?
Richard K. Brown and Andree Proulx Perspectives on Scheduling
Alain Donzel
Jorge Carmona
and L. Andrew Corkan Data Retrieval
Handling
and Integration
edited by John P. Devlin Introduction
John P. Devlin Database Systems
Barr E. Bauer Systems Integration
Chip Allee Data Management and Tracking for Natural Product Programs
Gregg R. Dietzman Laboratory Design and Management
edited by Matthew A. Sills Introduction
Matthew A. Sills Planning and Implementing an HTS Program
Matthew A. Sills and Mark Crawford Establishing an HTS Program in a Start-up Biotechnology Company
Michael D. Boisclair
James Schultz
and Dan Maloney