The objective of the study was to explore the effects of Pulmonary Tuberculosis(PTB) as a co-morbid condition in HIV+ adults and its effects on neurocognitive functions in Zambia. The study will help in understanding the impact and effects of Pulmonary Tuberculosis (PTB) on the HIV+ Zambian adults and how far it affects the neurocognitive functions. The study will also help in determining implications for treatment, adherence and use of CNS penetrating antiretroviral, anti-TB regimens, rehabilitation programmes, Human resource replacements at work and care. It will help clinicians determining as when to start treatment to protect the CNS from damage and promote continued quality of life/productivity over the lifespan. Results suggested that all the seven domains are affected by PTB except motor domain.