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The practice of surgical pathology in modern times has become increasingly complex and sophisticated and has moved from a strictly morphologic science to one that encompasses the study of disease biology in intricate detail, utilizing histochemical, immunohistochemical, and various molecular techniques. Tumor pathology, in particular, has transcended its role as a "diagnostic" science and has become essential for guiding treatment and establishing prognosis. Every technique born in this his new era in tumor pathology, however, is essentially guided by the nuances of morphologic characterization described by our predecessors. Pattern recognition is perhaps the most fundamental skill a pathologist should possess - the foundation upon which the entire field of anatomic pathology is built. In this manual, as in surgical pathology, science meets art.