Non-infectious CXCR4-tropic HIV induces T-Cell death and possibly AIDS - Kibirige, Catherine;Margolick, Joseph
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A gradual decline in CD4 T-Cells is the main hallmark of HIV infection. At the "T-Cell inflection point", there is an accelerated CD4 T-Cell decline and the onset of CD8 T-Cell decline, leading up to Aquired Immune Deficiency Syndrome (AIDS). Strains of HIV that can bind the CXCR4 co-receptor emerge prior to this, suggesting that they contribute to immune failure by inducing death in naive, CXCR4-bearing T-Cells. Naive T-Cells are critical for replenishing the immune system after any kind of T-Cell loss. Additionally, the vast majority of HIV virions circulating during infection are defective…mehr

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Produktbeschreibung
A gradual decline in CD4 T-Cells is the main hallmark of HIV infection. At the "T-Cell inflection point", there is an accelerated CD4 T-Cell decline and the onset of CD8 T-Cell decline, leading up to Aquired Immune Deficiency Syndrome (AIDS). Strains of HIV that can bind the CXCR4 co-receptor emerge prior to this, suggesting that they contribute to immune failure by inducing death in naive, CXCR4-bearing T-Cells. Naive T-Cells are critical for replenishing the immune system after any kind of T-Cell loss. Additionally, the vast majority of HIV virions circulating during infection are defective and non- infectious. Their effects on immune cells are not clearly understood. In this study, primary peripheral blood T-cells were exposed to inactivated, non-infectious, HIV-1 virions. The study shows that when T-cell subsets were purified and isolated from each other, CXCR4- tropic virions induce a significantly greater decline in the number of naive, CD4 T-cells as opposed to the CCR5-tropic strains which initiate HIV infection (P=0.013). The emergence of CXCR4-utilizing HIV virions later on during infection may therefore contribute to the development of AIDS.
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Autorenporträt
Catherine N. Kibirige, PhD, studied at the University of Bath, UK and then the Johns Hopkins University, USA. She is now an HIV Research Scientist with the Henry M. Jackson Foundation. Joseph B. Margolick, MD, PhD, is a Professor at the Johns Hopkins University and was Catherine''s PhD advisor. His research focuses on HIV immuno-pathogenesis.