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The ultimate intention of this work is to achieve a better understanding of how some critical factors for the successful application of knowledge management (KM) can effect on e-business in International companies. Besides, this study prepares a framework discriminating three dimensions of e-business: e-information,e-communication and e-workflow. KM covers an extensive range of usefulness and sustains various sets of activities and supposed that the KM success, are the Key Success Factors (KSFs) on the contributions of quality and quantity to the system. Therefore, to achieve the research objective, this work limits the field of investigation to that key success factors for KM, devoted to the formalization and the sharing of best practices and experiences within the organization and also examination of the influences and relationships between KSF and e-business. The outcomes confirm positive relationships between all five KFS parameters but there is a lack of leadership. Moreover, there are highly positive relationships among the three dimensions of e-business. At last, the KFS has a significant effect on e-business as well.